Mouse Hepatitis Virus (MHV) | Charles River - Charles River …
Pertinent information about mouse hepatitis virus (MHV), such as affected species, transmission, clinical signs and lesions, diagnosis, inference with research, as well as prevention and treatment.
Mouse Hepatitis Virus (MHV) - College of Veterinary Medicine
Clinical Signs: MHV is usually subclinical in immunocompetent mice. Disease expression is dependent on virus species and on host factors, including age, genotype, experimental status and immune function. There are two major patterns of disease based on the tropism of the virus strain.
Mouse hepatitis virus - PMC - National Center for Biotechnology …
Aug 1, 2001 · Depending on the strain used, mouse hepatitis virus (MHV) causes a variety of diseases, such as enteritis, hepatitis and demyelinating encephalomyelitis, in susceptible rodents . Infection of susceptible strains of mice with strain MHV-3 results in severe hepatitis caused, in part, by overexpression of prothrombinase [2] .
Mouse Hepatitis Virus - PMC - National Center for …
Sep 2, 2007 · This chapter attempts to provide an overview of the important aspects of mouse hepatitis virus (MHV) experimental biology while emphasizing the virus as a naturally occurring mouse pathogen. Even this is complicated, as it is impossible to generalize with this virus, due to marked differences in the biologic behavior of the myriad virus strains ...
Mouse Hepatitis Virus Receptor as a Determinant of the Mouse ...
Feb 24, 2012 · In this review, we report that the receptor of mouse hepatitis virus (MHV), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), is an important determinant of mouse susceptibility to MHV infection.
A Mouse Model of MHV‐1 Virus Infection for Study of Acute and …
Oct 23, 2023 · Current models used for research, such as non-human primates and transgenic mice, are expensive and require scarce Biosafety Level-3 (BSL-3) laboratories, thereby limiting their practicality. However, the mouse hepatitis virus 1 …
The most effective way to eradicate MHV infections is to cull the colony and obtain clean replacement stock. However, this is not always a feasible option when working with valu-able mice. Caesarian rederivation or embryo transfer can be used to produce offspring that have not been exposed to the virus. Repeated serological evaluations should ...
Basic reproduction numbers of three strains of mouse hepatitis …
Jan 5, 2022 · Mouse hepatitis virus (MHV) is a murine coronavirus and one of the most important pathogens in laboratory mice. Although various strains of MHV have been isolated, they are generally excreted in the feces and transmitted …
Mouse hepatitis virus - ScienceDirect
Aug 1, 2001 · Suckling C57BL/6 mice infected with MHV are protected from developing acute encephalitis by nursing with dams previously immunized to MHV. However, a significant fraction of these mice later develops demyelinating encephalomyelitis.
Mouse Hepatitis Virus, a coronavirus specific to mice, is a highly contagious disease, although it does not persist in the environment. MHV is transmitted via aerosols, fomites, and direct contact. It can also contaminate cell cultures and transplantable tumors and be introduced into colony mice via those routes.